OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.

Product information

CAS Number: 479080-38-1

Molecular Weight: 390.44

Formula: C22H22N4O3

Chemical Name: (3E,5S)-N-methoxy-5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-{2'-methyl-[1,1'-biphenyl]-4-carbonyl}pyrrolidin-3-imine

Smiles: CO/N=C1\C[C@@H](C2=NC(C)=NO2)N(C\1)C(=O)C1C=CC(=CC=1)C1=CC=CC=C1C

InChiKey: PFGOHCJFGDEHAX-HBTCSRNFSA-N

InChi: InChI=1S/C22H22N4O3/c1-14-6-4-5-7-19(14)16-8-10-17(11-9-16)22(27)26-13-18(25-28-3)12-20(26)21-23-15(2)24-29-21/h4-11,20H,12-13H2,1-3H3/b25-18+/t20-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Oxytocin (OT) is a nonapeptide hormone that acts on the OT receptor, a seven-transmembrane (7TM) (Gq-coupled) receptor. The OT receptor has no subtypes but is related to the vasopressin receptors V1A, V1B and V2. OT antagonists have therapeutic potential in a number of areas including pre-term labour: Benign Prostatic Hyperplasia and sexual dysfunction. As a result there is significant interest in the identification of potent, selective, orally bioavailable OT antagonists.

Products are for research use only. Not for human use.